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Winter effect and preventing scarring

Presented By
Prof. Hillary Baldwin, Acne Treatment and Research Center
AAD 2018

There is increasing evidence that acne pathophysiology may include a barrier defect. Acne medications are also often drying. An improvement of the barrier may improve acne, a fact that is often not addressed in acne therapy.

“The distinct vehicle response often seen in trials with topical medications may be due to improvement of barrier,” said Prof. Hillary Baldwin of the Acne Treatment and Research Center [1]. In to her experience, this barrier improvement is part of a successful acne management.

“Patients are happier when physicians also address the dryness of their skin,” she said. Patients with moderate-to-severe acne have a higher transepidermal water loss (TEWL) compared with control subjects [2]. An impaired water barrier function may be responsible for comedo formation, since barrier dysfunction is accompanied by hyperkeratosis of the follicular epithelium.

A current trial showed that ceramides in the stratum corneum undergo seasonal variations over t...

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