Patients suffering from pemphigus or bullous pemphigoid often have various comorbidities . They also are at risk for a lower bone mineral density through factors such as long-term steroid medication, inflammation, and low vitamin D. Dr Raj Chovatiya (Northwestern University Feinberg School of Medicine, USA) and his colleagues investigated whether there is an association between the risk for osteoporosis or pathologic fractures and pemphigus or bullous pemphigoid patients, and also looked for fracture predictors. The authors analysed data from over 198 million people of all ages that received treatment in emergency rooms all over the USA from 2006-2012. Among these adults and children were 4,502 cases of pemphigus and 8,863 of bullous pemphigoid.
After adjusting for risk factors such as sex, age, income, previous long-term steroids, and insurance, there was still a significantly elevated risk of osteoporosis and pathologic fractures in pemphigus patients...
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