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Histological remission predicts relapse-free survival in ulcerative colitis

Conference
ECCO 2019

Histological grade is an important prognostic marker in ulcerative colitis patients in clinical and endoscopic remission. Histological remission independently predicts significantly longer relapse-free survival and, thus, may be a superior therapeutic target compared with endoscopic remission.

These were the main conclusions drawn from a single-centre study that aimed to assess histological activity using the validated Nancy histological activity score as a predictor of future relapse [1]. Enrolled were 74 ulcerative colitis patients in both clinical and endoscopic remission attending a tertiary centre in Canberra, Australia, between 2015 and 2018. Clinical remission was defined as partial Mayo score (MSp) <2, and endoscopic remission was defined as Mayo Endoscopic Subscore (MES) ≤1. Median follow-up was 42 months, the median relapse free period 30 months.

Patients with MES 0 (P=0.02) and histological remission (P≤0.0001) had a significantly long...



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