Histological grade is an important prognostic marker in ulcerative colitis patients in clinical and endoscopic remission. Histological remission independently predicts significantly longer relapse-free survival and, thus, may be a superior therapeutic target compared with endoscopic remission.
These were the main conclusions drawn from a single-centre study that aimed to assess histological activity using the validated Nancy histological activity score as a predictor of future relapse . Enrolled were 74 ulcerative colitis patients in both clinical and endoscopic remission attending a tertiary centre in Canberra, Australia, between 2015 and 2018. Clinical remission was defined as partial Mayo score (MSp) <2, and endoscopic remission was defined as Mayo Endoscopic Subscore (MES) ≤1. Median follow-up was 42 months, the median relapse free period 30 months.
Patients with MES 0 (P=0.02) and histological remission (P≤0.0001) had a significantly long...
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Table of Contents: ECCO 2019
New Compounds: Study Results
Short-term and Long-term Treatment Results
Complementary and Alternative Medicine
Basic and Preclinical Research
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