Medical writer: Tim Donald, ELS
Lurbinectedin, an inhibitor of activated transcription, showed notable anti-tumour activity as a second-line treatment in small cell lung cancer (SCLC) in a phase II clinical trial, according to a June 1 presentation (Abstract 8506).
“Lurbinectedin is an active single agent in second-line SCLC,” said presenter Luis G. Paz-Ares, MD, PhD, of Hospital Universitario 12 de Octubre, CNIO, and Universidad Complutense and Ciberonc, Spain. “Anti-tumour activity has been observed in sensitive patients, with an overall response rate [ORR] of 45%. But also, in a setting where we have very few opportunities for treatment, in the setting of resistance, with ORR of 22.2%.”
In addition, the safety profile was favorable, and side effects were easily managed, he said. There were low percentages of treatment-related serious adverse events (SAEs) and of discontinuation due to adverse events (AEs), and there were no toxic deaths.
please login to read the entire article:
You need to register to read the entire article, please do so now.
« Sentinel Lymph Node Biopsy Shows Promise for Early Oral Cancer Next Article
Novel RET Inhibitor BLU-667 Offers Promise for RET+ Advanced NSCLC »
Table of Contents: ASCO 2019
Head and Neck Cancer
Genitourinary Cancer - Prostate Cancer
Developmental Therapeutics - Immunotherapy
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.