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Short Methotrexate Stop Is Safe in Patients with RA

Presented By
Dr Min Jung Kim, Seoul National University Hospital, South Korea
Conference
EULAR 2019

Temporary cessation of methotrexate for 2 weeks is safe and has no effect on rheumatoid arthritis (RA) disease activity. Discontinuing methotrexate for 4 weeks is linked to a temporary increase in disease activity without affecting long-term health outcomes.

“In special circumstances, including infections, vaccinations, or major surgeries, the use of methotrexate should be minimised to restore the treatment-associated immune suppression. However, the effect of short-term methotrexate cessation on disease activity remains unknown.

“We previously reported two randomised control trials showing that short-term methotrexate discontinuation can significantly improve immunogenicity after seasonal influenza vaccination in patients with RA,” said Dr Min Jung Kim (Seoul National University Hospital, South Korea). In the presented study, post-hoc analysis compared the effects of methotrexate discontinuation for 2 or 4 weeks on vaccine response to seasonal infl...



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