Home > Dactolisib Phase 2b Clinical Trial Data Shows Reduction of Respiratory Tract Infections in Senior Asthma Patients

Dactolisib Phase 2b Clinical Trial Data Shows Reduction of Respiratory Tract Infections in Senior Asthma Patients

Dr Joan Mannick (resTORbio Inc, USA) presented new results from a phase 2b trial in which >900 65+ year old adults were treated with 10 mg dactolisib once daily for 16 weeks during the winter cold and flu season [1]. Dactolisib was observed to improve immune function by upregulation of antiviral gene expression and to significantly reduce the incidence of respiratory tract infections (RTIs) in senior adults with asthma.

Dactolisib is an oral, selective, and potent inhibitor of target of rapamycin complex 1 (TORC1). Dactolisib 10 mg once daily was observed to reduce the percentage of patients 65 years of age and older with asthma who developed laboratory-confirmed RTIs by 68.9% as compared with placebo (P=0.0001) and the rate of all RTIs (with or without laboratory confirmation) by 58.2% as compared with placebo (P=0.0002). Furthermore, the incidence of RTIs caused by multiple different viruses including rhinovirus (the most common viral cause of asthma exa...



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