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Comprehensive profiling in localised stage lung cancer

Neoadjuvant targeted therapy and immunotherapy have shown a promising clinical effect for localised stage non-small cell lung cancer (NSCLC). At the ELCC 2019, the first prospective study integrating the correlation of genomic alteration and T cell receptor (TCR) in localised surgical lung adenocarcinomas (LUAD) was presented.

The characteristics and relationship of genomic and immune profiling in surgical LUAD has been poorly delineated to date.

100 consecutive patients

Dr Ke-Zhong Chen (Peking University People’s Hospital, Beijing, China) and colleagues prospectively enrolled 100 consecutive patients with pulmonary nodule who intended to undergo curative lung resection.
They investigated the TCR repertoire using next-generation deep sequencing of the complementarity determining region 3 (CDR3) of the TCR β-chain in tissue and white blood cell samples. Target-capture deep sequencing of 1,021 genes was used to detect ge...



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