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Promising results of tildrakizumab in psoriatic arthritis

A phase 2B study (TIL trial) showed superior efficacy and comparable safety of tildrakizumab versus placebo in patients with psoriatic arthritis (PsA). Treatment-emergent adverse events (AEs) in the tildrakizumab-treated group were uncommon. These were the main conclusions presented by Dr P. Mease (University of Washington, USA) at EULAR 2019 [1].

PsA, a chronic inflammatory disease, affects the joints, causing pain and disability. Tildrakizumab is a high-affinity, human, monoclonal antibody targeting interleukin (IL)-23p19. Tildrakizumab, classified as a biological disease-modifying anti-rheumatic drug (bDMARD), is currently approved to treat moderate-to-severe plaque psoriasis [2,3]. According to current guidelines, bDMARDs, targeting IL-12/23 or IL-17 pathways may be considered in patients who have had an inadequate response to conventional synthetic DMARDs, and for whom TNF inhibitors are not appropriate.

The 24-week, randomised, double-blind, p...



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