Results suggest that DOACs are associated with lower rates of stroke/systemic embolism (SE) and varying rates of major bleeding compared with warfarin in frail non-valvular atrial fibrillation (AF) patients .
AF is the most common arrhythmia in the elderly, and it is an independent risk factor for stroke . Also, the prevalence of frailty increases steadily with age, from approximately 4% at 65-69 years of age to nearly 26% at 85 years or above . It is estimated that non-valvular AF patients have a 4-times higher odds of being classified as frail than patients without non-valvular AF , and despite the high prevalence of AF among frail elderly patients, fewer frail AF patients receive oral coagulants compared with non-frail patients [5,6]. Even so, very few real-world studies have examined the comparative efficacy and safety outcomes between non-vitamin K antagonist oral coagulants (DOACs) and warfarin in the frail elderly non-valvular AF populat...
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Table of Contents: ACC 2019
Acute and Stable Ischaemic Heart Disease
Arrhythmias and Clinical Electrophysiology
Congenital Heart Disease
Heart Failure and Cardiomyopathies
Pulmonary Arterial Hypertension and Venous Thromboembolism
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