The retrospective study of obese non-valvular atrial fibrillation (AF) patients who initiated apixaban, dabigatran, rivaroxaban, or warfarin between January 2013 and September 2015 showed that there is no difference between these DOACs with regard to stroke/systemic embolism (SE) rates when compared with warfarin . Apixaban had a lower rate of major bleeding but it was not significantly different for dabigatran or rivaroxaban in comparison to warfarin.
These results, presented by Dr Steven Deitelzweig (Ochsner Health System, USA), were derived from the ARISTOPHANES population and pooled CMS Medicare data with 4 US commercial claims databases. This covers >180 million beneficiaries annually (approximately 56% of the US population). A total of 62,143 obese patients (19.3 %) with non-valvular AF were included: 13,130 (21.1%) on apixaban, 5,349 (8.6%) on dabigatran, 20,278 (32.6%) on rivaroxaban, and 23,386 (37.6%) on warfarin. Propensity score matching...
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Table of Contents: ACC 2019
Acute and Stable Ischaemic Heart Disease
Arrhythmias and Clinical Electrophysiology
Congenital Heart Disease
Heart Failure and Cardiomyopathies
Pulmonary Arterial Hypertension and Venous Thromboembolism
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