Dr Arthur Labovitz (University of South Florida, USA) presented the initial results of the pilot, open-label, parallel-group, multicentre, randomised controlled Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation (AREST) trial .
The study intended to determine the optimal timing of anticoagulation initiation after atrial fibrillation (AF)-induced acute ischaemic stroke (AIS), which is associated with larger infarct volumes. Previous landmark randomised trials have all waited weeks or months to begin anticoagulation after a stroke, but this trial aimed to establish the clinical value of early intervention. To that end, the safety and efficacy of early anticoagulation were evaluated based on stroke size, secondary prevention of ischaemic stroke, and risks of subsequent haemorrhagic transformation.
Patients were randomised 1:1 to receive early apixaban...
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Table of Contents: AHA 2019
New Approaches to CVD Risk Reduction
Interventional Management for Acute Coronary Syndrome
Results for the Ischemia Trials: To Intervene or Not to Intervene
Controversies in Contemporary Management of Aortic Stenosis
Guidelines: Updates and Controversies
Trials in Electrophysiology and Left Ventricular Function
New Frontiers in Lipid Therapy
Challenges in Heart Failure Management
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