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BNP still a reliable prognostic marker before and during sacubitril/valsartan treatment

Conference
ACC 2019
Trial
PARADIGM-HF

Despite an initial increase in B-Type Natriuretic Peptide (BNP) after initiation of treatment with sacubitril/valsartan in approximately 60% of patients, it has been assessed that BNP remains a reliable prognostic marker before and during treatment with sacubitril/valsartan [1]. Natriuretic peptides are substrates of neprilysin, and BNP concentrations rise with neprilysin inhibition. This has led to research into the clinical validity of measuring BNP in sacubitril/valsartan-treated patients and the use of N-terminal pro-BNP (NT-proBNP) being preferred and recommended.

Vaduganathan et al. aimed to determine the prognostic performance of BNP before and during treatment with sacubitril/valsartan. Data was analysed from the randomised, double-blind, parallel group, active-controlled PARADIGM-HF trial, which compared the long-term efficacy and safety of sacubitril/valsartan with enalapril in patients with HFrEF [1,2]. BNP measurements were analysed in a centra...



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