Supplementation with omega-3 fatty acid may have a dose-related protective effect on coronary events. Furthermore, there may also be a dose-related adverse effect on non-fatal arrhythmias, according to recent additional data from the ASCEND trial.
Although higher fish consumption has long been associated with lower risks of coronary heart disease (and especially of cardiac deaths in observational studies), the evidence so far has been inconclusive with conflicting outcomes in various studies and meta-analyses [1-3]. Prof. Sarah Parish (University of Oxford, United Kingdom) presented additional data of the randomised ASCEND trial which assessed the effects of omega-3 fatty acid supplementation on arrhythmias from linkage to electronic Hospital Episode Statistics data during trial for 97% of patients (and for 14 years before randomisation). A total of 15,480 UK patients were included, aged ≥40 years, who had diabetes (any type) and no prior cardiovascular di...
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Table of Contents: ESC 2019
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