An Italian study investigated coagulation cascade activation in the context of chronic spontaneous urticaria [CSU]. The identified D-Dimer values were correlated to disease activity.
The exact pathogenesis of mast cell activation in CSU is still not entirely clear . Recent findings imply a role not only of the immune system dysregulation and activation of the inflammatory cascade, but also of the coagulation pathway in CSU pathogenesis. Dr Antonio Cristaudo (San Gallicano Dermatological Institute, Italy) and his colleagues looked into the involvement of coagulation factors . They were particularly interested in a possible capacity of D-dimers and/or prothrombin fragments F1+2 to anticipate treatment response to omalizumab in CSU patients. 40 patients were included into the trial. Prerequisite for enrolment was the presence of wheals with or without presence of angioedema for ≥ 6 weeks. Laboratory testing was performed for activation markers of comple...
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