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Cannabinoids: a future role in dermatology?

Endocannabinoids are extremely frequent in all skin structures. Preliminary data shows that there is an emerging potential of cannabinoids for different indications in dermatology.

In general, there are 3 kinds of cannabinoids: the endocannabinoids occurring in the brain and body, phytocannabinoids in plants like hemp, and synthetic cannabinoids made in the laboratory. “I think the latter are most interesting for medical use because they are designed with a specific purpose, and we will see the best outcomes of them,” said Prof. Adam Friedman (School of Medicine & Health Sciences, USA) [1].

Cannabinoids address 2 kind of receptors. CB1 is the principal receptor in the central nervous system that regulates transmission of noxious stimuli. Peripherally, it gates the propagation of pain signals. The CB2 receptor is located on immune cells and suppresses the local secretion of pro-inflammatory factors. This receptor is found in the spleen, tonsils, thym...

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