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Continuous terbinafine most effective for toenail onychomycosis

A systematic review investigating efficacy and safety of continuous versus pulsed therapy for treating toenail onychomycosis revealed no significant beneficial regimen in general. However, mycological cure had the greatest success with continuous terbinafine 250 mg over 24 weeks [1,2].

Onychomycosis is the most common of all nail diseases and has different treatment options. A network meta-analysis aimed to examine the most effective of these treatment options with regard to mycological cure. The analysis included 22 studies with data from 4,205 study subjects and targeted randomised controlled trials of oral antifungal therapy for adults for toenail onychomycosis, diagnosed by potassium hydroxide solution (KOH) and culture. The assessment evaluated terbinafine, itraconazole, and fluconazole in continuous and pulsed regimes at different dosages: 250 mg terbinafine (continuous for 12, 16, and 24 weeks), 500 mg terbinafine (pulsed for 3 or 4 months), 200 mg ...

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