Soft molecule highly efficacious in hyperhidrosis
Hyperhidrosis has an impact on QoL comparable to, or greater than, psoriasis or eczema . According to the International Hyperhidrosis Society, sweat production of >100 mL/5 min. in males, and >50 mL/5 min. in females is defined as hyperhidrosis. A new gel with a soft molecule was shown to be effective in reducing hyperhidrosis after a treatment period of only eight days .
“The anticholinergic drug sofpironium bromide is a soft molecule, which means that it is easily broken down and rapidly metabolised in the bloodstream” explained Dr Stacey Smith, a dermatologist in Encinitas, California. It inhibits acetylcholine-driven sympathetic and parasympathetic actions on various exocrine glands, including sweat glands [Figure 4].
This new molecular entity has the advantage of a better local therapeutic effect with fewer systemic side effects. The efficacy and safety of this agent was ass...
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