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Hyperhidrosis: Soft molecule and anticholinergic towelettes

Dr Adelaide Hebert, University of Texas Health Science Center, USA
AAD 2018

Soft molecule highly efficacious in hyperhidrosis

Hyperhidrosis has an impact on QoL comparable to, or greater than, psoriasis or eczema [12]. According to the International Hyperhidrosis Society, sweat production of >100 mL/5 min. in males, and >50 mL/5 min. in females is defined as hyperhidrosis. A new gel with a soft molecule was shown to be effective in reducing hyperhidrosis after a treatment period of only eight days [13].

“The anticholinergic drug sofpironium bromide is a soft molecule, which means that it is easily broken down and rapidly metabolised in the bloodstream” explained Dr Stacey Smith, a dermatologist in Encinitas, California. It inhibits acetylcholine-driven sympathetic and parasympathetic actions on various exocrine glands, including sweat glands [Figure 4].

This new molecular entity has the advantage of a better local therapeutic effect with fewer systemic side effects. The efficacy and safety of this agent was ass...

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