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Understanding genetics to unravel psoriasis and atopic dermatitis pathogenesis

Expert
Prof. Jonathan Barker, Kings College London, United Kingdom
Conference
SPIN 2019

Recent advances in psoriasis and eczema genetics have not only led to innovative interventions and new drug pipelines, in some cases they also allow us to distinguish which patient responds better to which biologic treatment. Prof. Jonathan Barker (Kings College London, United Kingdom) discussed the direct clinical implications that psoriasis and atopic dermatitis (AD) genetics have realised [1]. Furthermore, the main genetic determinant for psoriasis, HLA-C*06:02, directs an autoimmune response against melanocytes through autoantigen presentation in psoriasis through ADAMTSL5, a melanocyte autoantigen [2].

Heritability is major factor of AD and psoriasis, as demonstrated in twin studies, where identical twins have a 25% concordance, whereas fraternal twins have only slightly higher concordance than the general population [1]. If a cohort has large numbers of adequately phenotyped patients, genome-wide association scanning (GWAS) can be an excelle...



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