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Atopic dermatitis and psoriasis: on a spectrum?

Expert
Prof. Emma Guttman-Yassky, Mount Sinai Medical School, USA
Conference
SPIN 2019

Prof. Emma Guttman-Yassky (Mount Sinai Medical School, USA) shakes down the similarities and differences between psoriasis vulgaris and chronic atopic dermatitis (AD) and concludes that they fall under the same pathomechanistic umbrella but with very distinct features [1].

For example, both psoriasis vulgaris and chronic AD are generally characterised by nearly indistinguishable histological psoriasiform dermatitis. At a mechanistic level we can classify both diseases as epidermal hyperplasia responses to certain cytokines produced by activated T cells in skin lesions, though the cytokines differ per disease [2]. About 12 years ago, a study comparing the expression of the proliferation marker Ki-67 by immunohistochemical staining of frozen sections of psoriasis and AD demonstrated that epidermal hyperplasia was equally evident in both psoriasis and AD [3]. This same study also found a similar extent of T cell infiltration in both the dermis and the epider...



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