Prof. Richard Langley (Dalhousie University, Canada) contended that the value of small molecules will persist during the era of biologics . Tailored use, careful patient selection, and patient preference are all important determining factors when choosing apremilast or TYK2 inhibition.
Many small molecules are being developed for psoriasis. They are small (<700 Da), chemically synthesised, generally simpler, well-defined, stable, and can be orally administered. Often, they are less expensive as well. Biologics, on the other hand, are generated in cell culture, are larger (>700 Da), and have complex tertiary structures with post-translational modifications; and the targets for biologics are usually extracellular (like anti-IL-17/-23) not intracellular (like small molecules). Currently, 3 (in some places 4) anti-TNF biologics are available: 1 anti-IL-12/23, 3 anti-IL-17s, and 4 anti-IL-23s, and many new molecules are coming out. In total, there are ...
please login to read the entire article:
You need to register to read the entire article, please do so now.
Table of Contents: SPIN 2019
Aetiology: Triggers and Risk Factors
Advances in Therapy
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.