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Early stages of gastric metaplasia: molecular profiling

Dr William Waddingham, University College London, United Kingdom
UEGW 2019

Gastric cancer precursors initiate as a clonal patch, expand by natural drift, and are characterised by a private set of somatic mutations.

Dr William Waddingham (University College London, United Kingdom) started by stating that intestinal metaplasia (IM) can be easily identified by histopathological identification of goblet cells and expression of markers such as CDX2. However, he warned, “the gap in our understanding of the pre-tumour progression is substantial” [1].

Even though the infection rate of H. pylori is extensive, the rate of progression, even at advance stages of chronic gastritis, is less than 1 in 200 per year. The current study aimed to answer three questions: (1) How is gastric IM initiated? (2) How do metaplastic foci spread and expand?; and (3) What are the molecular differences between patches of IM (diversity)? To address these questions, the researchers developed a technique of harvesting a strip of submucosal tissue ...

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