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Isatuximab triplet improves PFS in R/R MM

The triplet therapy of isatuximab, carfilzomib, and dexamethasone gave a significant improvement in progression-free survival (PFS) versus carfilzomib and dexamethasone alone in patients with relapsed/refractory multiple myeloma (R/R MM).

Prof. Philippe Moreau (University Hospital of Nantes, France) presented the interim results of the open-label phase 3 IKEMA study [1]. This study randomised 302 patients with relapsed/refractory myeloma who had previously received 1 to 3 lines of therapy to receive either intravenous isatuximab at 10 mg/kg plus carfilzomib and dexamethasone (n=179) or carfilzomib/dexamethasone alone (n=123). Isatuximab was administered weekly for 4 weeks, and then every 2 weeks. Carfilzomib was administered at 20 mg/m2 on the first 2 days and then 56 mg/m2 twice-weekly thereafter for 3 to 4 weeks, followed by twice-weekly dexamethasone at 20 mg. Treatment was given until diseas...

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