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Microbiome predicts B-ALL predisposition

Researchers have used mouse models to demonstrate that the gut microbiome profile can function as biomarker to identify predisposed carriers at risk to develop leukaemia. Furthermore, in these models, microbiome deprivation via antibiotic treatment is a risk factor for leukaemia development.

Dr Carolina Vincente-Dueñas (Institute of Biomedical Research of Salamanca, Spain) presented the pre-clinical data [1], in which her lab tested the hypothesis of whether the gut microbiome may serve as an integration hub for environmental signals that modulate the risk of developing B-cell acute lymphoblastic leukaemia (B-ALL), by using a murine model of human B-ALL (*Pax5*+/- mice).

*Pax5*+/- mice were raised in either a normal environment, or an infection-free environment. The host-gut microbiome of *Pax5*+/- mice was compared with wildtype mice in both environments. Previous studies have shown that a normal environment increased the incidence of B-ALL in thes...

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