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Factor V Leiden mutation linked to atrial fibrillation

A novel cohort analysis from the Tromsø Study found that specifically men with factor V Leiden (FVL) mutation have an elevated risk for atrial fibrillation. However, FVL mutation was not identified as a general risk factor for ischaemic stroke [1].

Atrial fibrillation is an established prothrombotic disease that may lead to ischaemic stroke. The FVL mutation is known to be a risk for venous thromboembolism and is also connected with arterial disease and unfavourable outcomes of pregnancies in carriers. The aim of this sub-analysis, presented by PhD student Erin Mathiesen Hald (UiT The Arctic University of Norway, Norway), was to evaluate a possible association of FVL with atrial fibrillation and successive ischaemic stroke.

This analysis included data form a randomly selected sub-cohort of 3,663 subjects from the fourth survey of general population within the Tromsø Study (1994/1995). Blood samples from all participants were analysed for FVL genotyp...



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