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Crosstalk between inflammation and coagulation in severe COVID-19 infections

In a special session at this year's virtual meeting, member of the ISTH COVID-19 Task Force Prof. Roberta Gualtierotti (University of Milan, Italy) highlighted haemostatic changes in patients with severe COVID‐19 [1].

Transmission of the novel coronavirus occurs via direct contact or respiratory droplets. The virus enters by binding to the ACE2 receptor expressed on bronchial and alveolar epithelial cells, endothelial cells, and monocytes in the lung. "Evidence speaks in favour of the role of endothelial cells in severe COVID-19, both as culprits and victims of the inflammatory state and consequent coagulopathy," Prof. Gualtierotti explained.

While most infections lead to mild-to-moderate respiratory symptoms, about 5% of the patients progress to a more severe and systemic disease with acute lung injury, eventually leading to acute respiratory distress syndrome, shock, and multiple organ dysfunction associated with a peculiar coagulopathy and an inc...



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