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Higher thrombotic risk in NSCLC patient with ALK rearrangement

A retrospective observational study showed that anaplastic lymphoma kinase gene (*ALK*) rearrangement in lung cancer patients is associated with a 3 to 4 times elevated thrombotic risk compared with *ALK*-negative lung cancer patients [1].

Chromosomal translocations involving *ALK* are rare oncogenic events found in 3-5% of non-small-cell lung cancers (NSCLC). Prior studies have shown that *ALK* rearrangement in NSCLC patients might confer an elevated risk for cancer-associated venous thromboembolism (VTE). Dr Hanny Al-Samkari (Massachusetts General Hospital, USA) and colleagues compared the risk for VTE and arterial thrombosis of 400 NSCLC patients with *ALK* rearrangement with 800 NSCLC patients without *ALK* rearrangement who were treated between 2009 and 2019. They performed multivariable time-to-event analysis to assess the risk of first venous or arterial thrombosis in both groups and controlled for covariates that impact thrombotic risk, e.g. known ...



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