Home > Haematology > ASH 2019 > Inclusive Medicine > Socioeconomic disparities and survival in paediatric AML

Socioeconomic disparities and survival in paediatric AML

Expert
Dr Lena E. Winestone, UCSF Benioff Children’s Hospital, USA
Conference
ASH 2019
Trial
Phase 3, AAML0531 and AAML1031

Children with acute myeloid leukaemia (AML) from low-income neighbourhoods enrolled in phase 3 clinical trials were 2.4 times more likely to die during treatment than children from middle- and high-income neighbourhoods [1].

Dr Lena E. Winestone (UCSF Benioff Children’s Hospital, USA) presented the first study to demonstrate that socioeconomic status, including income and educational status, is a key contributor to survival disparities in children with AML. Researchers concluded the origin of this disparity was not from chemotherapy, but that paediatric AML patients from low-income and low-education zip codes have lower 5-year overall survival compared with patients from middle-income and higher-educated zip codes.

Data for this evaluation was obtained from 1,467 children enrolled in the Children’s Oncology Group’s 2 recent phase 3 clinical trials AAML0531 and AAML1031. Patients were assessed by the income level of their postal code and by the avera...



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