Matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1 year compared with chronic transfusions. Furthermore, MSD-HSCT was also associated with changes in highest TCDs at 3 years, normalisation rate at 1 year, and ferritin levels at 1 and 3 years .
In the late-breaking plenary session, Dr Francoise Bernaudin (Intercommunal Hospital Center de Créteil, France) presented their study data showing that increased TCD in children with sickle cell anaemia (SCA) is associated with an increased risk of ischaemic stroke, stenosis, and silent cerebral infarcts. Previous studies have identified the pivotal role of chronic transfusions in reducing stroke risk, while newer studies have considered other preventive approaches such as hydroxyurea or MSD-HSCT. The DREPAGREFFE study is a nonrandomised, controlled, open-label intervention st...
please login to read the entire article:
You need to register to read the entire article, please do so now.
« CAR-T cell therapy in ALL as breakthrough advance Next Article
Treating thalassemia twice, in mice »
Table of Contents: EHA 2019
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.