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Overcoming the “don’t eat me” signal in AML and MDS

Dr David Sallman, Moffitt Cancer Center, USA
EHA 2019

Antileukaemic activity was observed with anti-CD47 macrophage checkpoint inhibitor 5F9, both as monotherapy and in combination with azacytidine, in patients with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS), as presented by Dr David Sallman (Moffitt Cancer Center, USA) [1].

5F9 is a novel form of immunotherapy that targets CD47 to restore innate immunity, the first line of defence against cancer cells. CD47 provides the notorious “don’t eat me” signal displayed by many types of cancer cells that enables macrophage immune evasion by preventing phagocytosis. CD47 is the dominant macrophage checkpoint that is overexpressed in most cancer cells, and increased CD47 expression has been associated with poorer prognosis. In addition, azacitidine can upregulate the pro “eat-me” signals, and in an aggressive AML xenograft preclinical model, the combination of 5F9 and azacitidine significantly improved overall survival vs either azacitidine or 5F9...

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