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MRI-based clustering of MS patients

An attempt to find clusters of multiple sclerosis (MS) patients with homogeneous underlying pathophysiology by using advanced MRI techniques resulted in the identification of 5 clusters [1]. The authors conclude that MRI-based clustering of MS patients is feasible and contributes to demonstrating disease heterogeneity. This may be useful for personalised medicine.

The heterogeneity in clinical manifestations, natural history, and treatment response of MS patients is due to underlying pathophysiological differences, which have only been partially clarified and classified. Researchers from IRCCS San Raffaele (Italy) set out to identify hierarchical clusters of MS patients based on age- and sex-adjusted MRI variables. They selected 115 MS patients along with 44 age- and sex-matched healthy controls (HC) to undergo brain and cervical cord 3T MRI with pulse sequences. Of the MS cohort, 57 patients had relapsing-remitting MS, 12 primary progressive MS, and 46 se...

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