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Non-Alzheimer’s disease pathophysiology in the elderly

Primary central nervous system pathologies leading to cognitive decline include a variety of only partially known conditions that can coexist to various extents with Alzheimer’s disease (AD) pathology. Availability of biomarkers as well as clinical profiling is still limited. In a lecture, Prof. Philip Scheltens (Amsterdam UMC, the Netherlands) focused on suspected non-Alzheimer’s disease pathophysiology (SNAP) [1].

Prof. Scheltens explained that SNAP is a biomarker-based concept denoting AD-like neurodegeneration in individuals without β-amyloidosis. Its prevalence is 20-30% in cognitive healthy individuals; it accounts for 20-40% of patients presenting to memory clinics. SNAP may be caused by cerebrovascular disorders, mixed pathologies (dementia with Lewy bodies, frontotemporal lobar degeneration), or non-AD neurodegeneration, such as primary age-related tauopathy (PART) and limbic-predominant age-related TDP-43 encephalopathy (LATE).

In the ATN ...

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