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News on AD biomarkers

New insights into biomarkers for Alzheimer's disease (AD) were shared in 3 studies.

One study evaluated the ability of EEG alone or with resting state functional MRI (rsfMRI) to characterise mild cognitive impairment (MCI) subjects with an AD-like cerebrospinal fluid (CSF) biomarker profile [1]. A total of 39 AD, 86 MCI, and 86 healthy subjects underwent EEG and/or rsfMRI. MCI subjects were differentiated into phosphorylated tau/Aβ1-42 ratio ≥0.13 (MCI-ATpos) and <0.13 (MCI-ATneg). In AD patients, delta and theta densities were increased, and alpha2 and beta1 densities decreased. MCI-ATpos individuals had higher theta density than MCI-ATneg individuals. After the application of rsfMRI networks to current source density analysis, the alpha2 band could distinguish MCI-ATpos patients from MCI-ATneg, AD, and healthy individuals. The authors concluded that theta frequency was the most sensitive to AD-like CSF biomarker profile. These results emphasis...

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