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Diastolic dysfunction novel risk factor for cognitive impairment

Increasing diastolic dysfunction is associated with more difficulty with executive functioning and with increasing cerebral small vessel disease, as demonstrated by white matter hyperintensities on brain imaging. These observations strongly suggest diastolic dysfunction to be a novel, modifiable risk factor for cognitive impairment and dementia [1].

Systolic dysfunction has an important effect on cardiovascular outcomes and is associated with cognitive decline [2]. The relationship between diastolic dysfunction and cognition is undefined, however. To this end, Parker et al. analysed echocardiographic, MRI, and neuropsychological data, collected between 2005-2008 in 1,438 participants >55 years in the Framingham Heart Study Offspring Cohort.

The outcomes demonstrated that an increasing E/E’ ratio (early mitral filling/diastolic mitral annular velocity) was associated with increased incident mild cognitive impairment (HR 1.29; 95% CI 1.01-1.66; P<0.0...



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