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Thrombus location and length predictors of early neurological deterioration

A large retrospective observational study in patients with minor strokes with large vessel occlusion found that thrombus location and length are strong predictors of early neurological deterioration (END) [1]. This may help to select the best candidates for additional endovascular therapy.

Researchers from Paris, France conducted the multicentre observational study MINOR-STROKE in which they included 721 patients with intravenous thrombolysis-treated minor strokes (NIH Stroke Scale/Score [NIHSS] ≤5) with large vessel occlusion intended for intravenous thrombolysis alone, including those patients who eventually received thrombectomy because of END. END was defined as a ≥4-point NIHSS increase within 24 hours after admission. Mean age of participants was 70 years, median NIHSS was 3. Occlusion was located in the internal carotid artery (ICA)-T/L in 3%, in the tandem cervical ICA+middle cerebral artery in 10%, in the proximal M1 in 7%, in the distal M1 in 21%...



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