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Early edoxaban may be safe after cardioembolic stroke

The optimal timing for starting oral anticoagulation after a stroke or transient ischaemic attack (TIA) in patients with nonvalvular atrial fibrillation (NVAF) is unknown. The observational SATES study of early treatment with edoxaban showed early initiation of edoxaban seems to be safe after a cardioembolic stroke [1].

New direct oral anticoagulants (DOACs), of which edoxaban is an example, are recommended for stroke prevention in NVAF patients. SATES was a prospective study to evaluate the safety of initiation within 72 hours of full dose edoxaban in NVAF patients after acute ischaemic stroke. The primary endpoint was safety in terms of any major bleeding in the first 3 months of treatment. Secondary endpoints were incidence of major bleeding, haemorrhagic transformation, and symptomatic haemorrhagic transformation rate, 3±2 days after the start of edoxaban treatment.

A total of 50 patients were enrolled, with a mean age of 77 years and a mean NIH...



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