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PDD and DLB represent two different disorders

EAN 2019

Lewy body dementias include two conditions, Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB).

In an analysis of 64 brain donors (52 PDD, 12 DLB), multiple clinical and neuropathological differences between PDD and DLB were observed [1]. This result supports the hypothesis that PDD and DLB represent two different disorders. Compared to PDD patients, DLB patients had:

  • shorter disease duration (P<0.001);
  • older age at motor symptoms onset (P=0.022);
  • less frequent tremor (P=0.017);
  • no dyskinesia (P<0.001);
  • less severe parkinsonism at the time of dementia (P<0.001);
  • lower MMSE scores (P=0.006).

DLB patients took less levodopa, dopamine agonists, monoamine oxidase inhibitors, amantadine, and anticholinergics compared to PDD patients. Alzheimer’s disease neuropathology scores were significantly higher in DLB vs PDD (B-score P=0.018; C-score P=0.016).

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