Inflammation may start early in Parkinson's disease (PD), long before motor symptoms occur, according to Prof. Vidar Gundersen (University of Oslo, Norway) in a plenary talk about the central theme of EAN 2019: “Neuroinflammation” .
In PD, microglia are activated and are present in dopamine neurons long before the accumulation of α-synuclein pathology. This implies that microglial activation probably contributes to the development of α-synuclein pathology . Early activation of microglia has also been demonstrated in translocator protein (TSPO) PET imaging . Both pro- and anti-inflammatory cytokines are activated, such as TNF and IL-1-beta. The pro-inflammatory cytokine IFN-gamma is also involved in inflammatory-induced neurodegeneration in PD .
Prof. Gundersen went on to explain how inflammation may contribute to dopamine neurodegeneration. He suggested that the adaptive immune system is involved in PD pathology and that PD might even be...
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Table of Contents: EAN 2019
Alzheimer’s Disease and other Dementias
Parkinson's Disease and other Movement Disorders
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