Home > Oncology > WCLC 2018 > Spread through air spaces is prognostic in lung neuroendocrine tumours

Spread through air spaces is prognostic in lung neuroendocrine tumours

Aly et al. previously reported that spread through air spaces (STAS) is associated with a worse prognosis in resected lung adenocarcinoma and squamous cell carcinoma [2, 3]. The aim of the current study was to investigate the incidence and prognostic impact of STAS in lung neuroendocrine tumours [4]. All tumour slides (median 3, range 2-7) from patients with primary lung neuroendocrine tumours (n=628) were evaluated for the presence of STAS. Cohorts included typical carcinoid (TC, n=305), atypical carcinoid (AC, n=38), large-cell neuroendocrine carcinoma (LCNEC, n=93), and small-cell lung carcinoma (SCLC, n=57). Patients with combined neuroendocrine tumours were excluded from the study (n=19). Aly et al. used the competing risks approach to analyse the cumulative incidence of recurrence and lung cancer-specific cumulative incidence of death.

STAS was identified in 25% neuroendocrine tumours. The TC cohort accounted for 15%; AC, 37%; LCNEC, 43%; SCLC, 46%. There were too fe...



please login to read the entire article:


You need to register to read the entire article, please do so now.





Posted on