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Prognostic value of distant organ-specific metastases in newly diagnosed lung neuroendocrine tumours

Lung neuroendocrine tumours are rare neoplasms with poor outcomes for patients with distant metastases. Nonetheless, the prognostic value of metastatic sites remains unclear. Wen et al. used the SEER database to fill this knowledge gap [5]. They extracted data on clinical-pathological characteristics, specific metastatic sites, and outcomes of stage 4 lung neuroendocrine tumours from the SEER database from 2010 to 2014. Estimates of OS and lung cancer-specific survival were based on the Kaplan-Meier method. Comparisons were developed using log-rank tests and Cox regression models.

The study included 12,337 patients with stage 4 neuroendocrine tumours. The 5-year OS was 10.7%; it was 18.3% for lung cancer-specific survival. At diagnosis, 2,159 patients had specific organ metastases to the liver, lungs, bone, or brain. The liver was the most common metastatic site (n=1,183 patients; 50.6%), followed by bone (n=801; 34.3%), lung (n=701; 29.9%), and brain (n=616; 26.4%). Patie...



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