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Pembrolizumab quadruples survival in selected advanced non-small cell lung cancer patients

Pembrolizumab quadrupled pre-immunotherapy era 5-year survival rates for patients when used as initial therapy (23.2% vs 5.5 %). For patients who received prior therapies, pembrolizumab increased survival rates to 15.5%. Across both patient populations studied, 5-year survival rates were highest among those whose tumours had PD-L1 expression of 50% or more vs 1-49% (as initial therapy arm: 29.6% vs 15.7%; prior therapy arm: 25% vs 12.6%) [1].

Five-year data from the phase 1b KEYNOTE-001 clinical trial show that pembrolizumab was safe and effective and substantially increased overall survival for advanced non-small cell lung cancer (aNSCLC). Specifically, 23.2% of people who had not previously been treated with chemotherapy and 15.5% of previously treated patients were alive after 5 years, with the greatest benefit observed in patients with higher PD-L1 expression. This represents a marked improv...



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