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Effect of veliparib with or without cisplatin in breast cancer: results of SWOG S1416

The Southwest Oncology Group (SWOG) 1416 phase II trial was designed to compare the efficacy of the PARP inhibitor veliparib plus cisplatin versus cisplatin alone in patients with metastatic and/or locally recurrent triple-negative breast cancer (TNBC) or *BRCA1* or *BRCA2* germline mutation–associated HER2-negative metastatic breast cancer. Priyanka Sharma, MD, of the University of Kansas Medical Center, presented the results of this trial during the ASCO20 Virtual Scientific Program [1].

Eligible patients were randomly assigned 1:1 to receive either treatment with cisplatin 75 mg/m2 on day 1 combined with veliparib 300 mg orally twice daily (BID) on days 1 to 14 (21-day cycle) or cisplatin 75 mg/m2 on day 1 plus placebo BID on days 1 to 14 (21-day cycle). Dr. Sharma noted that the veliparib 300 mg BID dose in this trial is much higher than that used in other studies such as BROCADE 3 [2].

After being randomly assigned, all pa...



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