The open-label, multicentre, randomised, phase 3 PHOEBE study compared pyrotinib plus capecitabine versus lapatinib plus capecitabine in metastatic HER2-positive breast cancer patients. Results showed an improvement in progression-free survival (PFS) and multiple secondary endpoints. The pyrotinib combination therapy is now approved in China as second-line standard-of-care for this patient group.
Pyrotinib is a small-molecular, irreversible, pan-ErbB receptor kinase inhibitor targeting EGFR, HER2, and HER4 . In previous phase 2 and phase 3 studies, pyrotinib in combination with capecitabine has shown clinically meaningful benefits and tolerability on patients with metastatic HER2-positive breast cancer after prior treatment with taxanes, anthracyclines, and/or trastuzumab. Pyrotinib plus capecitabine showed better overall response rates (ORR) and PFS compared with lapatinib plus capecitabine, which was standard second line of care for these patients in ...
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Breast & Ovarian Cancer
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