Home > Oncology > Second-line gemcitabine plus ramucirumab significantly improves overall survival

Second-line gemcitabine plus ramucirumab significantly improves overall survival

To date, second-line chemotherapy is not the standard of care in patients with malignant pleural mesothelioma (MPM). The multicenter, double-blind, randomised phase 2 RAMES study explored the efficacy and the safety of the addition of the antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2/KDR) ramucirumab to gemcitabine as the second-line treatment in MPM patients after platinum/pemetrexed regimens.

The RAMES study enrolled 161 patients with progressive disease after first-line treatment with platinum/pemetrexed. Patients were randomised to gemcitabine (1,000 mg/m2 IV on days 1 and 8 every 21 days) plus placebo or gemcitabine plus ramucirumab (10 mg/kg IV on day 1, of a 21-day cycle), until tolerability or progressive disease. Median number of courses was 3.50 in the gemcitabine/placebo arm and 7.50 in the gemcitabine/ramucirumab arm. The primary endpoint of the trial was overall survival (OS). Secondary endpoints were ...



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