Prof. Ann Partridge (Dana-Farber Cancer Institute, Boston, USA) addressed the relevance of clinical benefit, clinical meaningfulness, and shared decision-making in the treatment of patients with early breast cancer.
Due to improvements in local and systemic treatments, the age-adjusted breast cancer mortality rate has gradually dropped in the last decades: from about 70 per 100,000 women (40-84 years) in the 1970’s to <40 per 100,000 women now. In light of the improved outcomes of the treatment, the definition of clinical benefit of a treatment has also evolved, Partridge said. In the 1970’s, clinical benefit meant that a patient had an objective response to the treatment. In the 1980’s, overall survival, quality of life, and physical functioning became objective parameters to define benefit. Since the 1990’s, the definition is mainly related to surrogate parameters like progression-free survival, overall response rates, durability of responses (in part...
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Table of Contents: BCC 2019
St. Gallen Consensus
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