Randomised clinical trials are the gold standard for assessing the efficacy of an intervention. However, their results are not always generalisable to real-world populations. Prof. Sharon Giordano (MD Anderson, Houston, USA) sketched how real-world data sometimes can fill this gap.
Although being the gold standard, randomised clinical trials have a couple of shortcomings that challenge the application of the outcomes of the trials when treating real-world patients, Giordano said. First of all, clinical trials don’t include (all) representative populations. In general, patients who participate in clinical trials are younger than the average real-world patient, have less comorbidities, have a better performance status, have a higher social-economic status, and often more late-stage cancer. As a consequence, it is not clear whether or not results of the clinical trial are also applicable to patient populations who where excluded from the trial, in particular ...
please login to read the entire article:
You need to register to read the entire article, please do so now.
« Largest Safety Study of Its Kind with Atezolizumab in Metastatic Bladder Cancer Next Article
Letter from the Editor »
Table of Contents: BCC 2019
St. Gallen Consensus
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.