Home > Oncology > BCC 2019 > St. Gallen Consensus > Extrapolating Data from Clinical Trials as We Treat Patients in Real Life

Extrapolating Data from Clinical Trials as We Treat Patients in Real Life

Presented By
Prof. Sharon Giordano, MD Anderson, Houston, USA
Conference
BCC 2019
Trial
APHINITY, KATHERINE, ExteNET

Randomised clinical trials are the gold standard for assessing the efficacy of an intervention. However, their results are not always generalisable to real-world populations. Prof. Sharon Giordano (MD Anderson, Houston, USA) sketched how real-world data sometimes can fill this gap.

Although being the gold standard, randomised clinical trials have a couple of shortcomings that challenge the application of the outcomes of the trials when treating real-world patients, Giordano said. First of all, clinical trials don’t include (all) representative populations. In general, patients who participate in clinical trials are younger than the average real-world patient, have less comorbidities, have a better performance status, have a higher social-economic status, and often more late-stage cancer. As a consequence, it is not clear whether or not results of the clinical trial are also applicable to patient populations who where excluded from the trial, in particular ...



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