Home > Oncology > ELCC 2019 > Optimal Management of Brain Metastases in NSCLC > Incidence and Local Treatment

Incidence and Local Treatment

Presented By
Prof. Michael Weller, University Hospital Zurich, Switzerland
Conference
ELCC 2019

Lung cancer is one of the primary tumours that very often spreads to the brain. If a patient presents with brain metastases of unknown origin, it is very likely that those are lung cancer metastases. Surgical removal of these lesions is not necessarily a good option, even when possible.

Approximately 13-44% of lung cancer patients develop central nervous system (CNS) metastasis; 50-60% of CNS metastases are from lung cancer. The incidence of CNS metastasis is rising, because patients are currently living longer and there is a better detection of metastasis using MRI [1,2].

Is there still a role for surgery?

Factors favouring intensified local therapy are the presence of a single or solitary metastasis, adequate performance status, no or mild neurological deficits, no or stable (>3 months) extracranial tumour manifestations, and the presence of a radioresistant tumour. “Apart from logical reasoning there is hardly any evide...



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