Written by: Prof. Zuzana Diamant
Affiliations: Skane University Hospital Lund, Sweden and University Medical Center Groningen, the Netherlands
Asthma is a highly prevalent disorder associated with comorbidities, affecting over 350 million people worldwide and imposing a significant health and socioeconomic burden . In 2015, as many as 400,000 asthma deaths have been reported .
Traditionally, asthma is diagnosed by (a history of) symptoms including wheeze, dyspnoea, chest tightness, and/or cough in combination with variable, often reversible, airway narrowing. Hallmarks of asthma underlying its clinical presentation include chronic airway inflammation, airway hyperresponsiveness, and structural changes within the airways referred to as ‘’airway remodelling’’. These characteristics are interrelated and have been shown to be more prominently present in uncontrolled disease . Indeed, severe exacerbations reflecting an intense flair-up of...
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