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Predicting Community-acquired Pneumonia Outcomes by microRNA Testing

Presented By
Dr Francisco Sanz Herrero, University Hospital of Valencia, Spain
ERS 2019

Community-acquired pneumonia (CAP) bears the risk of complications like severe sepsis or acute respiratory failure. A recent study has found different types of microRNA that may anticipate the development of those deteriorations and could easily be tested [1].

The prospective observational study, presented by Dr Francisco Sanz Herrero (University Hospital of Valencia, Spain), included 169 patients with CAP, aged between 58 and 79 years (mean age 66.9 years), all hospitalised in Valencia. A substantial proportion of them had important comorbidities like diabetes (29%), COPD (28.4%), arrhythmia (13.6%), and cerebrovascular disease (8.9%).

During the CAP treatment of these patients, 109 developed a complication. Acute hypoxic respiratory failure (AHRF) and severe sepsis were seen in 25.4% and 13.6% of the study subjects. Real-time PCR testing found a downregulation of microRNA-223 and microRNA-574 that had a high accuracy in predicting the onset of severe sepsis (area ...

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