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Upadacitinib provides fast onset of improvement in psoriatic arthritis

In a double-blind, randomised controlled phase 3 trial, patients with psoriatic arthritis who have an inadequate response to ≥1 non-biologic disease-modifying anti-rheumatic drug (non-bDMARD) showed improvement in musculoskeletal symptoms, psoriasis, physical function, pain, and fatigue and inhibited radiographic progression when treated with upadacitinib. These improvements were seen by week 2; no new safety signals emerged [1].

Upadacitinib –an oral, reversible, Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis– is currently under evaluation for treatment of psoriatic arthritis. The SELECT-PsA-1 study, presented by Prof. Iain McInnes (University of Glasgow, Scotland), assessed the efficacy and safety of upadacitinib compared with placebo and adalimumab in patients with psoriatic arthritis and prior inadequate response or intolerance to ≥1 non-bDMARD. Participants ...



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