Main trial data from the head-to-head EXCEED trial showed that secukinumab monotherapy for biologic-naïve patients with active psoriatic arthritis is at least as efficacious as adalimumab monotherapy and provides higher responses on skin endpoints [1,3].
The EXCEED trial was a phase 3b study of patients with active psoriatic arthritis and an inadequate response or intolerance to conventional disease-modifying anti-rheumatic drugs (DMARDs). The trial compared the efficacy and safety of secukinumab and adalimumab as first-line biologic monotherapy through 52 weeks, with a musculoskeletal primary endpoint. The results were presented by Prof. Iain McInnes (University of Glasgow, United Kingdom), and simultaneously published in *The Lancet* [1,2].
Participants (n=853) were randomised to secukinumab 300 mg/week at weeks 0-4 and every 4 weeks thereafter (n=426) or adalimumab 40 mg subcutaneous ...
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Table of Contents: EULAR 2020
Osteoporosis and Osteoarthritis
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